伦敦政治经济学院开设有以下24个科系(或研究所):
会计系(Department of Accounting)
人类学系(Department of Anthropology)
经济学系(Department of Economics)
经济史系(Department of Economic History)
欧洲研究所(European Institute)
金融系(Department of Finance)
性别研究所(Gender Institute)
地理与环境系(Department of Geography & Environment)
政府学系(Department of Government)
国际发展系(Department of International Development)
国际史系(Department of International History)
国际关系系(Department of International Relations)
语言中心(Language Centre)
法学系(Department of Law)
管理系(Department of Management)
数学系(Department of Mathematics)
传媒系(Department of Media & Communications)
方法论系(Department of Methodology)
哲学、逻辑与科学方法系(Department of Philosophy, Logic and Scientific Method)
公共事务研究所(Institute of Public Affairs (IPA))
社会政策系(Department of Social Policy)
社会心理学系(Department of Social Psychology)
社会学系(Department of Sociology)
统计系(Department of Statistics)